Pectin | MedChemExpress (MCE)
产品名称: Pectin | MedChemExpress (MCE)
英文名称: Pectin
产品编号: HY-W145518
产品价格: 250; 500
产品产地: 美国
品牌商标: MedChemExpress (MCE)
更新时间: 2024-07-03T13:26:03
使用范围: null
规格 | 价格 |
100 mg; 1 g |
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Pectin
CAS No. : 9000-69-5
MCE 国际站:Pectin
产品活性:Pectin 是一种杂多糖,可从高等植物的细胞壁获得。Pectin 能够制成纳米颗粒,作为活性分子的运载载体。Pectin 也是一种吸附剂,一种广谱抗菌剂,可以结合肠道粘膜中的细菌毒素和其他刺激物,缓解受刺激的黏膜。
研究领域:Metabolic Enzyme/Protease | Anti-infection
作用靶点:Endogenous Metabolite | Bacterial | Antibiotic
In Vitro: Pectin (5 mg/mL; 24, 48, and 72 h) shows low cytotoxicity on HepG2 cells, and can be made into nanoparticles (PPN), encapsulating Paclitaxel (HY-B0015), decreases the Paclitaxel cytotoxicity (%) from 55.6% to 21.7% at 72 h.
Pectin (3, 6 mg/mL; 48 h) inhibits Staphylococcus aureus ATCC 25923 growth, with a minimum inhibitory concentration (MIC) of 40 mg/mL.
Pectin inhibits Gram-negative Helicobacter pylori, a common human pathogen, shows highest antibacterial activity at pH 5.0, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL and minimum bactericidal concentration (MBC) of 0.325 mg/mL.
Pectin displays lower antibacterial activity against E. coli with MICs of 25 mg/mL and 50 mg/mL and MBC values ranging between 25-50 mg/mL.
Pectin exhibits the antibacterial activity via its undissociated acid form.
In Vivo: Pectin serves as the nanoparticles encapsulating Paclitaxel (HY-B0015), (20 mg/kg; i.v.; single dose) significantly delays plasma clearance with detection of Paclitaxel possible up to 48 h in Balb/c mice.
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